Solution conformation of a cyclic neurokinin antagonist: A nmr and molecular dynamics study
β Scribed by Min Zhang; Thomas P. Quinn; Tuck C. Wong
- Publisher
- Wiley (John Wiley & Sons)
- Year
- 1994
- Tongue
- English
- Weight
- 766 KB
- Volume
- 34
- Category
- Article
- ISSN
- 0006-3525
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The conformation of two highly potent parathyroid hormone (PTH) antagonists was investigated in water/2,2,2-trifluoroethanol mixtures. The two peptides are derived9om the sequence and have a D -T v ~ replacing Gly in position 12. In the analogue derivedfrom PTHrP, Lys" was replaced by Leu to remove
## Abstract The conformation of cyclolinopeptide A [cβ(ProβProβPheβPheβLeuβIleβIleβLeuβVal)], a naturally occurring peptide with remarkable cytoprotective activity, has been investigated by means of molecular dynamics simulations in various molecular environments. Structural and dynamical propertie