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Synthesis and characterization of naphthalimide-containing peptide nucleic acid

✍ Scribed by Hisafumi Ikeda; Yushin Nakamura; Isao Saito

Book ID
104251557
Publisher
Elsevier Science
Year
2002
Tongue
French
Weight
175 KB
Volume
43
Category
Article
ISSN
0040-4039

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✦ Synopsis

Naphthalimide-containing PNA monomer unit 6 was synthesized for the preparation of PNAs containing a naphthalimide chromophore (NPNA). PNA oligomers were purified by reversed-phase HPLC and characterized by MALDI-TOF MS and UV spectra. Thermodynamic analyses revealed that the PNA oligomer containing a naphthalimide moiety at the amino terminal stabilizes PNA-DNA hybrids.

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