✦ LIBER ✦

Synthesis and characterization of flavin-tethered peptide nucleic acid

✍ Scribed by Hisafumi Ikeda; Kohzo Yoshida; Makoto Ozeki; Isao Saito

Book ID: 104230302
Publisher: Elsevier Science
Year: 2001
Tongue: French
Weight: 80 KB
Volume: 42
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(01)00228-3

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✦ Synopsis

We synthesized flavin-containing PNA monomer unit 5 from lumiflavin and prepared PNAs containing a flavin moiety (FPNA) by the standard tBoc chemistry. Each PNA oligomer was purified by reversed-phase HPLC and characterized by MALDI-TOF MS and UV spectra. Thermodynamic analyses indicated that the PNA oligomer containing a flavin moiety near the amino terminal considerably stabilized the PNA-DNA hybrids.

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