A selective, versatile, robust methodology for bifunctionalization of b-cyclodextrin is achieved allowing the attachment of peptides in varying C-and/or N-terminal combinations on resin using Fmoc SPPS. Two linkers are attached to cyclodextrin enabling selective binding to the resin (or a peptide at
Synthesis and characterization of mannosyl mimetic derivatives based on a β-cyclodextrin core
✍ Scribed by Yockot, Duplex; Moreau, Vincent; Demailly, Gilles; Djedaïni-Pilard, Florence
- Book ID
- 115520411
- Publisher
- Royal Society of Chemistry
- Year
- 2003
- Tongue
- English
- Weight
- 260 KB
- Volume
- 1
- Category
- Article
- ISSN
- 1477-0520
- DOI
- 10.1039/b301670f
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A convenient method for the synthesis of b-d-gluco-, b-d-galacto-, 2-acetamido-2-deoxy-b-d-gluco-and ad-mannopyranosylamine clusters based on cyclomaltoheptaose (b-cyclodextrin) is presented. The synthesis involves: 1) the one-pot synthesis of the acetylated chloroacetyl N-glycoside derivatives of d
The synthesis of three first-order dendrimers based on a b-cyclodextrin core containing fourteen Val, Phe and Val-Phe residues is described. The guest binding ability of the tetradecavalent peptidyl b-cyclodextrin derivative has been tested by calorimetric titration and the thermodynamic parameters