𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Synthesis of bifunctional peptide derivatives based on a β-cyclodextrin core with drug delivery potential

✍ Scribed by Rachel J. White; Paul G. Plieger; David R.K. Harding

Publisher
Elsevier Science
Year
2010
Tongue
French
Weight
397 KB
Volume
51
Category
Article
ISSN
0040-4039

No coin nor oath required. For personal study only.

✦ Synopsis

A selective, versatile, robust methodology for bifunctionalization of b-cyclodextrin is achieved allowing the attachment of peptides in varying C-and/or N-terminal combinations on resin using Fmoc SPPS. Two linkers are attached to cyclodextrin enabling selective binding to the resin (or a peptide attached to the resin). Continuation of peptide growth and/or cleavage from the resin follows, thus various combinations of peptide-cyclodextrin species are achieved. A model peptide (Gly-Ala) is used in this study to illustrate the potential of this system for attaching one or more bioactive peptides for drug transport and release purposes.

📜 SIMILAR VOLUMES

Synthesis of peptide dendrimers based on
Synthesis of peptide dendrimers based on a β-cyclodextrin core with guest binding ability
✍ Abdullah M.A. Muhanna; Emilia Ortiz-Salmerón; Luis Garcı́a-Fuentes; Juan J. Gimé 📂 Article 📅 2003 🏛 Elsevier Science 🌐 French ⚖ 247 KB

The synthesis of three first-order dendrimers based on a b-cyclodextrin core containing fourteen Val, Phe and Val-Phe residues is described. The guest binding ability of the tetradecavalent peptidyl b-cyclodextrin derivative has been tested by calorimetric titration and the thermodynamic parameters