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Synthesis and characterization of conotoxin IIIa

✍ Scribed by Stefan Becker; Eric Atherton; Hartmut Michel; Robert D. Gordon


Book ID
112587710
Publisher
Springer
Year
1989
Tongue
English
Weight
129 KB
Volume
8
Category
Article
ISSN
1573-4943

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## Abstract The 27‐residue polypeptide ω‐conotoxin GVIA (ω‐CgTx), from the venom of the cone shell __Conus geographus__, blocks N‐type neuronal calcium channels. It contains three disulphide bridges. We reporte here the synthesis and biological characterization of a seires of analogues in which one