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Synthesis and characterization of a disulfide bond isomer of omega-conotoxin GVIA

✍ Scribed by M.W. Pennington; S.M. Festin; M.L. Maccecchini; W.R. Kem

Book ID
116073048
Publisher
Elsevier Science
Year
1992
Tongue
English
Weight
545 KB
Volume
30
Category
Article
ISSN
0041-0101

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Synthesis and biological characterizatio
Synthesis and biological characterization of a series of analogues of Ο‰-conotoxin gvia
✍ James P. Flinn; Dr Roger Murphy; Jaroslav H. Boubliek; Michael J. Lew; Christine πŸ“‚ Article πŸ“… 1995 πŸ› John Wiley and Sons 🌐 English βš– 522 KB

## Abstract The 27‐residue polypeptide ω‐conotoxin GVIA (ω‐CgTx), from the venom of the cone shell __Conus geographus__, blocks N‐type neuronal calcium channels. It contains three disulphide bridges. We reporte here the synthesis and biological characterization of a seires of analogues in which one