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Synthesis of disulfide-bridged fragments of ω-conotoxins GVIA and MVIIA

✍ Scribed by SIMMONDS, ROBIN G. ;TUPPER, DAVID E. ;HARRIS, JOHN R.

Book ID: 115099655
Publisher: Wiley (Blackwell Publishing)
Year: 2009
Tongue: English
Weight: 380 KB
Volume: 43
Category: Article
ISSN: 0367-8377
DOI: 10.1111/j.1399-3011.1994.tb00532.x

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## Abstract The 27‐residue polypeptide ω‐conotoxin GVIA (ω‐CgTx), from the venom of the cone shell __Conus geographus__, blocks N‐type neuronal calcium channels. It contains three disulphide bridges. We reporte here the synthesis and biological characterization of a seires of analogues in which one