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Synthesis and central nervous system stimulant activity of camphor-1,2,4-benzotriazines fused with five and six-membered heterocycles

✍ Scribed by Shin-Ichi Nagai; Taisei Ueda; Masatoshi Takamura; Akito Nagatsu; Nobutoshi Murakami; Jinsaku Sakakibara

Publisher
Journal of Heterocyclic Chemistry
Year
1998
Tongue
English
Weight
298 KB
Volume
35
Category
Article
ISSN
0022-152X

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✦ Synopsis

Abstract

Novel camphor‐1,2,4‐triazines fused with imidazole 2–3, thiadiazole 4, 1,2,4‐triazole 7, pyrimidine 9–13 and 1,3,5‐triazine 14, were synthesized starting from (5__R__,8__S__)‐3‐amino‐5,9,9‐trimethyl‐5,6,7,8‐tetrahydro‐5,8‐methano‐1,2,4‐benzotriazine 1. Evaluation of central nervous system stimulant activity demonstrated that the presence of a N‐N group at C‐3 position of 1,2,4‐benzotriazine will be essential for the activity.

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