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Synthesis and Biophysical Characterization of Oligonucleotides Containing a 4′-Selenonucleotide

✍ Scribed by Watts, Jonathan K.; Johnston, Blair D.; Jayakanthan, Kumarasamy; Wahba, Alexander S.; Pinto, B. Mario; Damha, Masad J.

Book ID
126088497
Publisher
American Chemical Society
Year
2008
Tongue
English
Weight
186 KB
Volume
130
Category
Article
ISSN
0002-7863

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Novel oligonucleotide dimers containing hydroxamate linkages (15 and 16) were synthesized, incorporated into oligonucleotide sequences and studied for their hybridization properties with complementary DNA and RNA targets. The modi®ed oligonucleotides showed similar binding properties and enhanced re