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Synthesis and biological evaluation of [α-(1,5-disubstituted 1H-pyrazol-4-yl)benzyl]azoles, analogues of bifonazole

✍ Scribed by Giulia Menozzi; Luisa Mosti; Olga Bruno; Eleonora Lo Presti; Chiara Musiu; Silvia Longu; Paolo La Colla; Walter Filippelli; Giuseppe Falcone; Brunella Piucci


Book ID
114019493
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
110 KB
Volume
54
Category
Article
ISSN
0014-827X

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Synthesis of pinacol esters of 1-alkyl-1
✍ Alexandre V. Ivachtchenko; Dmitry V. Kravchenko; Valentina I. Zheludeva; Dmitry 📂 Article 📅 2004 🏛 Journal of Heterocyclic Chemistry 🌐 English ⚖ 128 KB

## Abstract Starting from 1__H__‐pyrazol, a wide number of 1‐alkyl‐1__H__‐pyrazol‐4‐yl and 1‐alkyl‐1__H__‐pyrazol‐5‐ylboronic acids and their pinacol esters were synthesized and characterized. The key step in the described methodology is the regioselective lithiation of the pyrazole ring. The synth