Synthesis and biological evaluation of unprecedented ring-expanded nucleosides (RENs) containing the imidazo[4,5-d][1,2,6]oxadiazepine ring system
✍ Scribed by D'Errico, Stefano; Oliviero, Giorgia; Amato, Jussara; Borbone, Nicola; Cerullo, Vincenzo; Hemminki, Akseli; Piccialli, Vincenzo; Zaccaria, Sabrina; Mayol, Luciano; Piccialli, Gennaro
- Book ID
- 120471011
- Publisher
- Royal Society of Chemistry
- Year
- 2012
- Tongue
- English
- Weight
- 730 KB
- Volume
- 48
- Category
- Article
- ISSN
- 1359-7345
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## Abstract The synthesis of a novel ring‐expanded nucleoside analogue, (Z)‐1‐((2‐Guanidinocarbamoyl‐cyclopropylidene)methyl)‐4,5,7,8‐tetrahydro‐6__H__‐6‐iminoimidazo[4,5‐__e__][1,3]diazepine‐4,8‐dione (**1**) has been reported. It was prepared starting from methyl imidazole‐4,5‐dicarboxylate by se