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Synthesis and biological evaluation of receptor-based tumor imaging agent: 99mTc-folate-glucaric acid

✍ Scribed by Mehmet Onursal; Fatma Yurt Lambrecht; Aykut Ozgur

Book ID
113655572
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
360 KB
Volume
416
Category
Article
ISSN
0378-5173

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## Abstract This work reports the synthesis, radiolabeling, and preliminary biodistribution results in tumor‐bearing mice of ^99m^Tc(CO)~3~(IDA‐CPT). The novel camptothecin (CPT) derivate was successfully synthesized by conjugation of iminodiacetic acid (IDA) to camptothecin via a short carbonyl‐me