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Synthesis and biological evaluation of 99mTc(CO)3(His–CB) as a tumor imaging agent

✍ Scribed by Wang, Jianjun; Yang, Jing; Duan, Xiaojiang; Zhang, Yanhua; Yang, Wenjiang; Liu, Yu

Book ID
121678614
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
411 KB
Volume
22
Category
Article
ISSN
0960-894X

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✍ Jianjun Wang; Tingting Niu; Jing Yang; Cunmin Tan; Xiaobei Zheng; Wangsuo Wu; Fe 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 French ⚖ 89 KB

## Abstract This work reports the synthesis, radiolabeling, and preliminary biodistribution results in tumor‐bearing mice of ^99m^Tc(CO)~3~(IDA‐CPT). The novel camptothecin (CPT) derivate was successfully synthesized by conjugation of iminodiacetic acid (IDA) to camptothecin via a short carbonyl‐me