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Synthesis and biological evaluation of .omega.-homologues of prostaglandin E1

✍ Scribed by Dajani, Esam Z.; Rozek, Leonard F.; Sanner, John H.; Miyano, Masateru


Book ID
125960838
Publisher
American Chemical Society
Year
1976
Tongue
English
Weight
579 KB
Volume
19
Category
Article
ISSN
0022-2623

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An Efficient Asymmetric Synthesis of Pro
✍ Ana RodrΓ­guez; Miguel Nomen; Bernd Werner Spur; Jean-Jacques Godfroid πŸ“‚ Article πŸ“… 1999 πŸ› John Wiley and Sons 🌐 English βš– 364 KB πŸ‘ 2 views

An asymmetric total synthesis of Prostaglandin E 1 (5) has with the Corey CBS catalyst gave the Ο‰-side chain 7 with ΟΎ96% ee. Conjugate addition using the reaction with been achieved in a two-component coupling process. The chiral hydroxycyclopentenone 6 was readily available from dilithiocyanocuprat