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Synthesis and Biological Evaluation of Novel Paclitaxel (Taxol) D-Ring Modified Analogues

✍ Scribed by Gunatilaka, A. A. Leslie; Ramdayal, Frank D.; Sarragiotto, Maria H.; Kingston, David G. I.; Sackett, Dan L.; Hamel, Ernest


Book ID
125982143
Publisher
American Chemical Society
Year
1999
Tongue
English
Weight
128 KB
Volume
64
Category
Article
ISSN
0022-3263

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Paclitaxel analogs modified in ring C: S
✍ Xian Liang; David G.I. Kingston; Byron H. Long; Craig A. Fairchild; Kathy A. Joh πŸ“‚ Article πŸ“… 1997 πŸ› Elsevier Science 🌐 French βš– 1017 KB

Lead tetraeetate oxidation of 6u-hydmxy-7-epi-paclitaxel leads to C-.or-paclitaxel and C-seco-paclitaxel derivatives. Tetrapropylammonium perruthenate (TPAP) oxidation of a 6tx-hydroxy-7-epi-paclitaxel derivative leads to a 6-formyl-C-nor-paclitaxel derivative. Reaction of a 6ot-O-trifluoromethanesu