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Synthesis and biological evaluation of novel methylene-bis-[1,5]-benzodiazepines

✍ Scribed by M. Raghu; A. Nagaraj; Ch. Sanjeeva Reddy

Publisher
Journal of Heterocyclic Chemistry
Year
2008
Tongue
English
Weight
351 KB
Volume
45
Category
Article
ISSN
0022-152X

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✦ Synopsis

Abstract

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A series of novel methylene‐bis‐chalcones 3 was prepared by the reaction of 5‐(3‐formyl‐4‐hydroxybenzyl)‐2‐hydroxy benzaldehyde 2 with different acetophenones, subsequent treatment of compound 3 with an appropriate o‐phenylenediamine gave the corresponding methylene‐bis‐[1,5]‐benzodiazepines 4/5 in good yields. Characterization of the new compounds has been done by means of IR, ^1^H NMR, MS and elemental analyses. The antibacterial and antifungal activity of the compounds has also been evaluated.

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