𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Synthesis and Biological Evaluation of Novel Rigid 1,4-Benzodiazepine-2,5-dione Chimeric Scaffolds

✍ Scribed by Ana C. Araújo; Francesco Nicotra; Cristina Airoldi; Barbara Costa; Gabriella Giagnoni; Pietro Fumagalli; Laura Cipolla

Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
320 KB
Volume
2008
Category
Article
ISSN
1434-193X

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Novel, conformationally constrained 1,4‐benzodiazepine‐2,5‐diones containing both a monosaccharide, fructose, and a proline moiety have been synthesized as chimeric scaffolds; preliminary biological evaluation as GABA~A~ receptor ligands is reported. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)

📜 SIMILAR VOLUMES

Synthesis of 1,4-Benzodiazepine-2,5-dion
Synthesis of 1,4-Benzodiazepine-2,5-dione Derivatives.
✍ Tong-Ing Ho; Wen-Shiong Chen; Chi-Wei Hsu; Yeun-Min Tsai; Jim-Min Fang 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 29 KB 👁 2 views

## Abstract For Abstract see ChemInform Abstract in Full Text.

Synthesis and biological evaluation of n
Synthesis and biological evaluation of novel methylene-bis-[1,5]-benzodiazepines
✍ M. Raghu; A. Nagaraj; Ch. Sanjeeva Reddy 📂 Article 📅 2008 🏛 Journal of Heterocyclic Chemistry 🌐 English ⚖ 351 KB

## Abstract magnified image A series of novel methylene‐bis‐chalcones **3** was prepared by the reaction of 5‐(3‐formyl‐4‐hydroxybenzyl)‐2‐hydroxy benzaldehyde **2** with different acetophenones, subsequent treatment of compound **3** with an appropriate __o__‐phenylenediamine gave the correspondi

ChemInform Abstract: Synthesis and Biolo
ChemInform Abstract: Synthesis and Biological Evaluation of Novel Methylene-bis-[1,5]-benzodiazepines.
✍ M. Raghu; A. Nagaraj; Ch. Sanjeeva Reddy 📂 Article 📅 2008 🏛 John Wiley and Sons ⚖ 22 KB 👁 2 views

## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable v

Solid-phase synthesis of a novel series
Solid-phase synthesis of a novel series of 2,3,4,5-tetrahydro-1,4-benzodiazepin-2,5-dione libraries
✍ Chiaki Migihashi; Fuminori Sato 📂 Article 📅 2003 🏛 Journal of Heterocyclic Chemistry 🌐 English ⚖ 70 KB

## Abstract An efficient solid‐phase synthetic method for 2,3,4,5‐Tetrahydro‐1,4‐benzodiazepin‐2,5‐diones, having amine derivatives on the benzene ring, was developed. This method has been successfully applied to the synthesis of several spatially separated drug‐like and information‐rich small‐mole