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Synthesis and biological study of novel methylene-bis-chalcones and substituted methylene-bis-pyrimidines/pyrimidinones

✍ Scribed by Adki Nagaraj; Cherkupally Sanjeeva Reddy

Publisher
Journal of Heterocyclic Chemistry
Year
2007
Tongue
English
Weight
303 KB
Volume
44
Category
Article
ISSN
0022-152X

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✦ Synopsis

Abstract

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A series of novel methylene‐bis‐chalcones was prepared by the reaction of 5,5′‐methylene‐bis‐salicylaldehyde with different acetophenones, subsequent treatment of methylene‐bis‐chalcones with urea/thiourea gave the corresponding methylene‐bis‐pyrimidinones/methylene‐bis‐mercaptopyrimidines in good yields. Characterization of the new compounds has been done by means of IR, ^1^H NMR, MS and elemental analysis. The antibacterial, antitubercular and antifungal activity of the compounds has also been evaluated.

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