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Synthesis and biological evaluation of novel bone-seeking [Re/99mTc(CO)3] complexes

✍ Scribed by Makris, George; Pirmettis, Ioannis; Papadopoulos, Minas S.; Papagiannopoulou, Dionysia

Book ID: 125828597
Publisher: Elsevier Science
Year: 2014
Tongue: English
Weight: 178 KB
Volume: 41
Category: Article
ISSN: 0969-8051
DOI: 10.1016/j.nucmedbio.2014.05.092

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## Abstract This work reports the synthesis, radiolabeling, and preliminary biodistribution results in tumor‐bearing mice of ^99m^Tc(CO)~3~(IDA‐CPT). The novel camptothecin (CPT) derivate was successfully synthesized by conjugation of iminodiacetic acid (IDA) to camptothecin via a short carbonyl‐me