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Synthesis and biological evaluation of a novel 99mTc cyclopentadienyl tricarbonyl complex ([(Cp-R)99mTc(CO)3]) for sigma-2 receptor tumor imaging

✍ Scribed by Chen, Xin; Cui, Meng-Chao; Deuther-Conrad, Winnie; Tu, Ying-Feng; Ma, Teng; Xie, Ying; Jia, Bing; Li, Yan; Xie, Fang; Wang, Xia; Steinbach, Jörg; Brust, Peter; Liu, Bo-Li; Jia, Hong-Mei


Book ID
123411359
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
459 KB
Volume
22
Category
Article
ISSN
0960-894X

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## Abstract This work reports the synthesis, radiolabeling, and preliminary biodistribution results in tumor‐bearing mice of ^99m^Tc(CO)~3~(IDA‐CPT). The novel camptothecin (CPT) derivate was successfully synthesized by conjugation of iminodiacetic acid (IDA) to camptothecin via a short carbonyl‐me