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Synthesis and biological evaluation of novel 2-vinyl carbapenems. Remarkable DHP-1 stability of 1′-substituted analogs

✍ Scribed by Akira Yamada; Kouji Hattori; Satoru Kuroda; Toshiyuki Chiba; Toshiaki Kamimura; Kazuo Sakane

Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
213 KB
Volume
6
Category
Article
ISSN
0960-894X

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✦ Synopsis

The synthesis, antibacterial activity and DHP-susceptibility of a series of novel 2-vinyl carbapenems is described. Carbapenems having a 1'-substituted vinyl moiety at the 2 position were found to be very stable toward DHP-1, displaying comparable stability to compounds with a 1 ~-methyl functionality.

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