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Synthesis and biological evaluation of N-(1-aziridino)-6-fluoro-quinolone-3-carboxylic acids

✍ Scribed by Sándor Bátori; Géza Tímári; István Koczka; István Hermecz

Book ID
104364601
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
262 KB
Volume
6
Category
Article
ISSN
0960-894X

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✦ Synopsis

acids (9a-i) were ~ynthesized and their antibacterial activities were tested against Gram-positive and Gramnegative micro-organisms. According to the MIC, all compounds studied are less active than Ciprofloxacin; two of them (ga,b) have similar activity as Nalidixic acid (1).

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✍ D. G. Markees; Linda S. Schwab 📂 Article 📅 1972 🏛 John Wiley and Sons 🌐 German ⚖ 489 KB 👁 2 views

## Abstract A modification of the Gould‐Jacobs reaction, particularly useful for the preparation of N‐alkyl‐4‐quinolone‐3‐carboxylic acids, is described. Decarboxylation of these acids leads to N‐alkyl‐4‐quinolones or, in the case of N‐ethyl‐benzo[h]‐4‐quinolone‐3‐carboxylic acid, to 4‐ethoxy‐benzo