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Synthesis and in vitro antibacterial activity of some 1 -(difluoromethoxyphenyl)quinolone-3-carboxylic acids

✍ Scribed by W. Xiao; R. Krishnan; Y.-I Lin; E. F. Delos Santos; N. A. Kuck; R. E. Babine; S. A. Lang Jr.

Publisher
John Wiley and Sons
Year
1989
Tongue
English
Weight
358 KB
Volume
78
Category
Article
ISSN
0022-3549

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## Abstract A modification of the Gould‐Jacobs reaction, particularly useful for the preparation of N‐alkyl‐4‐quinolone‐3‐carboxylic acids, is described. Decarboxylation of these acids leads to N‐alkyl‐4‐quinolones or, in the case of N‐ethyl‐benzo[h]‐4‐quinolone‐3‐carboxylic acid, to 4‐ethoxy‐benzo