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Synthesis and biological evaluation of lycorine derivatives as dual inhibitors of human acetylcholinesterase and butyrylcholinesterase

✍ Scribed by Wang, Yue-Hu; Wan, Qin-Li; Gu, Cheng-Ding; Luo, Huai-Rong; Long, Chun-Lin


Book ID
120391634
Publisher
Chemistry Central
Year
2012
Tongue
English
Weight
261 KB
Volume
6
Category
Article
ISSN
1752-153X

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## Abstract The synthesis of tacrine‐thiadiazolidinone hybrids is described. These compounds are designed as dual acetylcholinesterase inhibitors binding simultaneously to the peripheral and catalytic sites of the enzyme. All tested compounds exhibit significant AChE inhibitory activity. Competitio