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Synthesis and Biological Evaluation of (−)-Laulimalide Analogues

✍ Scribed by Wender, Paul A.; Hegde, Sayee G.; Hubbard, Robert D.; Zhang, Lei; Mooberry, Susan L.

Book ID
125941599
Publisher
American Chemical Society
Year
2003
Tongue
English
Weight
64 KB
Volume
5
Category
Article
ISSN
1523-7060

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✍ Andreas Gollner; Karl-Heinz Altmann; Jürg Gertsch; Johann Mulzer 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 516 KB

## Abstract **A sensitive family**: The first total synthesis of the antitumor agents neolaulimalide and isolaulimalide as well as a highly efficient route to laulimalide is described. A Kulinkovich reaction followed by a cyclopropyl–allyl rearrangement is used to install the __exo__‐methylene grou