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Total Synthesis and Biological Evaluation of 11-Desmethyllaulimalide, a Highly Potent Simplified Laulimalide Analogue

✍ Scribed by Wender, Paul A.; Hilinski, Michael K.; Soldermann, Nicolas; Mooberry, Susan L.


Book ID
126984475
Publisher
American Chemical Society
Year
2006
Tongue
English
Weight
91 KB
Volume
8
Category
Article
ISSN
1523-7060

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## Abstract **A sensitive family**: The first total synthesis of the antitumor agents neolaulimalide and isolaulimalide as well as a highly efficient route to laulimalide is described. A Kulinkovich reaction followed by a cyclopropyl–allyl rearrangement is used to install the __exo__‐methylene grou