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Design, synthesis and biological evaluation of novel, simplified analogues of laulimalide: modification of the side chain

✍ Scribed by Ian Paterson; Dirk Menche; Anders E. Håkansson; Adrian Longstaff; David Wong; Isabel Barasoain; Rubén M. Buey; J. Fernando Díaz

Book ID
108073611
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
203 KB
Volume
15
Category
Article
ISSN
0960-894X

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The Laulimalide Family: Total Synthesis
The Laulimalide Family: Total Synthesis and Biological Evaluation of Neolaulimalide, Isolaulimalide, Laulimalide and a Nonnatural Analogue
✍ Andreas Gollner; Karl-Heinz Altmann; Jürg Gertsch; Johann Mulzer 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 516 KB

## Abstract **A sensitive family**: The first total synthesis of the antitumor agents neolaulimalide and isolaulimalide as well as a highly efficient route to laulimalide is described. A Kulinkovich reaction followed by a cyclopropyl–allyl rearrangement is used to install the __exo__‐methylene grou