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Synthesis and biological evaluation of conformationally flexible as well as restricted dimers of monastrol and related dihydropyrimidones

✍ Scribed by Ahmed Kamal; M. Shaheer Malik; Shaik Bajee; Shaik Azeeza; Shaikh Faazil; Sistla Ramakrishna; V.G.M. Naidu; M.V.P.S. Vishnuwardhan


Book ID
108116609
Publisher
Elsevier Science
Year
2011
Tongue
French
Weight
408 KB
Volume
46
Category
Article
ISSN
0223-5234

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Synthesis of a conformationally restrict
✍ Wim M De Borggraeve; Frederik J.R Rombouts; Erik V Van der Eycken; Suzanne M Top πŸ“‚ Article πŸ“… 2001 πŸ› Elsevier Science 🌐 French βš– 84 KB

Dichloropyrazinone 3 was converted into a conformationally restricted dipeptide analogue 8 by means of a Diels-Alder strategy. The b-turn characteristics of molecule 8 were examined by molecular modeling and NMR spectroscopy.