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Synthesis and biological evaluation of C-1 and ring modified A-norpaclitaxels

โœ Scribed by Haiqing Yuan; David G.I. Kingston; Byron H. Long; Craig A. Fairchild; Kathy A. Johnston


Book ID
108379395
Publisher
Elsevier Science
Year
1999
Tongue
French
Weight
970 KB
Volume
55
Category
Article
ISSN
0040-4020

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Lead tetraeetate oxidation of 6u-hydmxy-7-epi-paclitaxel leads to C-.or-paclitaxel and C-seco-paclitaxel derivatives. Tetrapropylammonium perruthenate (TPAP) oxidation of a 6tx-hydroxy-7-epi-paclitaxel derivative leads to a 6-formyl-C-nor-paclitaxel derivative. Reaction of a 6ot-O-trifluoromethanesu