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Synthesis and biological evaluation of 3-benzyl-1-methyl- and 1-methyl-3-phenyl-isothioureas as potential inhibitors of iNOS

โœ Scribed by Nicola Paesano; Stefania Marzocco; Caterina Vicidomini; Carmela Saturnino; Giuseppina Autore; Giovanni De Martino; Gianluca Sbardella


Book ID
108073516
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
261 KB
Volume
15
Category
Article
ISSN
0960-894X

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Synthesis of 3-methyl-4-phenyl-3-butenam
โœ U. Valcavi ๐Ÿ“‚ Article ๐Ÿ“… 1974 ๐Ÿ› John Wiley and Sons ๐ŸŒ French โš– 230 KB ๐Ÿ‘ 1 views

## Abstract The syntheses of 3โ€methylโ€4โ€phenylโ€3โ€butenamide, an hypolipemic compound, labelled 1โ€^14^C (VIII) and N,Nโ€dideutero (XI) are described. The 2โ€methylโ€3โ€phenylโ€2โ€propenyl chloride (VI), reacting with cuprous cyanideโ€^14^C, gave the 3โ€methylโ€4โ€phenylโ€3โ€butenonitrileโ€1โ€^14^C (VII) which, tr