Disposition and pharmacokinetics of L-N6
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Ji Y. Zhang; Yuefen Wang; Mark N. Milton; Lori Kraus; Alan P. Breau; Susan K. Pa
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Article
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2004
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John Wiley and Sons
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English
โ 210 KB
The metabolism, pharmacokinetics, tissue distribution, and excretion of L-N6-(1-iminoethyl)lysine-5-tetrazole-amide (L-NIL-TA), a selective inducible NO synthase (iNOS) inhibitor, were investigated in rats. [ 14 C]L-NIL-TA is extensively metabolized after either oral or IV administration with a mino