Synthesis and biological activity of some PGE1 carbinols

✍ Scribed by Harold C. Kluender; G.P. Peruzzotti

• Book ID: 104235977
• Publisher: Elsevier Science
• Year: 1977
• Tongue: French
• Weight: 186 KB
• Volume: 18
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(01)83680-7

✦ Synopsis

Broad prostaglandin-like activity has been reported for 1-prostanols such as the PGElcarbinol, la.

1 However, when la was prepared in our laboratories it was found to show marked selectivity in its biological activity as compared to PGEl, 2.

2 The carbinol was found to be a relaxant of guinea pig tracheal tissue at levels similar to those observed for PGEl. On the other hand, the activity in the rat uterine strip in vitro and the cat and dog cardiovascular systems in viva for la was significantly less than that observed for 2. 0