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The synthesis and biological activity of ω-pentanor-15-alkylcyclobutyl-PGE1 analogs

✍ Scribed by H.C. Arndt; P.J. Gardiner; E. Hong; H.C. Kluender; C. Myers; W.D. Woessner

Book ID
119048758
Publisher
Elsevier Science
Year
1978
Tongue
English
Weight
510 KB
Volume
16
Category
Article
ISSN
0090-6980

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✍ Harold C. Kluender; G.P. Peruzzotti 📂 Article 📅 1977 🏛 Elsevier Science 🌐 French ⚖ 186 KB

Broad prostaglandin-like activity has been reported for 1-prostanols such as the PGElcarbinol, la. 1 However, when la was prepared in our laboratories it was found to show marked selectivity in its biological activity as compared to PGEl, 2. 2 The carbinol was found to be a relaxant of guinea pig