𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Synthesis and biological activity of novel 1-(2,3,4-trimethoxyphenyl)-2-{[5-(3,4,5-trimethoxyphenyl)-1,3,4-thiadiazol-2-yl]thio}ethanone oxime ester derivatives

✍ Scribed by Wei Xue; Baoan Song; Wei He; Hua Wang; Song Yang; Linhong Jin; Deyu Hu; Gang Liu; Ping Lu

Publisher
Journal of Heterocyclic Chemistry
Year
2006
Tongue
English
Weight
135 KB
Volume
43
Category
Article
ISSN
0022-152X

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

magnified image

In a search for new fungicide and anticancer agent with improved biological properties and different bioactivity spectrum, we designed and synthesized a series of novel oxime esters containing 1,3,4‐thiadiazole group in moderate yield starting from gallic acid. The title compounds were identified by IR, ^1^H NMR, ^13^C NMR and elemental analysis. The bioassay tests showed that these title compounds exhibit weak to moderate anticancer activity in vitro by MTT method.

📜 SIMILAR VOLUMES

ChemInform Abstract: In(OTf)3-Mediated F
ChemInform Abstract: In(OTf)3-Mediated Facile Preparation of 2-(3,4,5-Trimethoxyphenyl)-5- [(5-alkylthio-1,3,4-oxadiazol-2-yl)methylthio]-1,3,4-thiadiazole Derivatives in Aqueous Media.
✍ Qin Wu; Bao-An Song; Song Yang; Pinaki S. Bhadury; De-Yu Hu; Wei Xue; Lin-Hong J 📂 Article 📅 2008 🏛 John Wiley and Sons ⚖ 27 KB 👁 1 views

## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable v

Indium-mediated facile preparation of 2-
Indium-mediated facile preparation of 2-(heterocyclic thio)-1-(2,3,4-trimethoxyphenyl)ethanone in aqueous media
✍ Song Yang; Bao-An Song; Hua Zhang; De-Yu Hu; Lin-Hong Jin; Gang Liu 📂 Article 📅 2004 🏛 Journal of Heterocyclic Chemistry 🌐 English ⚖ 104 KB

## Abstract An environmentally benign and efficient process for the preparation of 1‐(2,3,4‐trimethoxyphenyl)‐2‐substituted heterocyclic thio ethanone derivatives was achieved by the reactions of mercapto compounds with 2‐bromo‐1‐(2,3,4‐trimethoxyphenyl)ethanone in water mediated by indium in very

Synthesis and antifungal activity of nov
Synthesis and antifungal activity of novel 5-substituted 4-(1,3,4-thiadiazol-2-yl)benzene-1,3-diols
✍ Joanna Matysiak; Alicja Skrzypek; Andrzej Niewiadomy 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 117 KB

## Abstract 5‐Substituted (amine, alkyl, aryl, heterocyclic) 4‐(1,3,4‐thiadiazol‐2‐yl)benzene‐1,3‐ diols were synthesized, and their antifungal properties were examined. The compounds were obtained by the one‐pot reaction of sulfinylbis((2,4‐dihydroxyphenyl)methanethione) with hydrazides or thiosem