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Indium-mediated facile preparation of 2-(heterocyclic thio)-1-(2,3,4-trimethoxyphenyl)ethanone in aqueous media

✍ Scribed by Song Yang; Bao-An Song; Hua Zhang; De-Yu Hu; Lin-Hong Jin; Gang Liu

Publisher: Journal of Heterocyclic Chemistry
Year: 2004
Tongue: English
Weight: 104 KB
Volume: 41
Category: Article
ISSN: 0022-152X
DOI: 10.1002/jhet.5570410423

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✦ Synopsis

Abstract

An environmentally benign and efficient process for the preparation of 1‐(2,3,4‐trimethoxyphenyl)‐2‐substituted heterocyclic thio ethanone derivatives was achieved by the reactions of mercapto compounds with 2‐bromo‐1‐(2,3,4‐trimethoxyphenyl)ethanone in water mediated by indium in very high yields. Antifungal activities of the compounds were examined and moderate activity was obtained.

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