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Synthesis and antifungal activity of novel 5-substituted 4-(1,3,4-thiadiazol-2-yl)benzene-1,3-diols

✍ Scribed by Joanna Matysiak; Alicja Skrzypek; Andrzej Niewiadomy

Publisher: John Wiley and Sons
Year: 2010
Tongue: English
Weight: 117 KB
Volume: 21
Category: Article
ISSN: 1042-7163
DOI: 10.1002/hc.20645

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✦ Synopsis

Abstract

5‐Substituted (amine, alkyl, aryl, heterocyclic) 4‐(1,3,4‐thiadiazol‐2‐yl)benzene‐1,3‐ diols were synthesized, and their antifungal properties were examined. The compounds were obtained by the one‐pot reaction of sulfinylbis((2,4‐dihydroxyphenyl)methanethione) with hydrazides or thiosemicarbazides. Their structures were identified from elemental, IR, ^1^H NMR, and MS spectra analyses. The activities of the derivatives against five phytopathogenic fungi in vitro were measured. Moderate fungicidal effect of the compounds under consideration was found. © 2010 Wiley Periodicals, Inc. Heteroatom Chem 21:533–540, 2010; View this article online at wileyonlinelibrary.com. DOI 10.1002/hc.20645

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