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Synthesis and biological activity of annulated pyrazoles as selective COX-2 inhibitors. I.

✍ Scribed by Hyun Hee Kim; Jae Gyu Park; Tae Chul Moon; Hyun Wook Chang; Yurngdong Jahng


Book ID
105673506
Publisher
Springer
Year
1999
Tongue
English
Weight
647 KB
Volume
22
Category
Article
ISSN
0253-6269

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✍ Michel ThΓ©rien; Christine Brideau; Chi Chung Chan; Wanda A. Cromlish; Jacques Yv πŸ“‚ Article πŸ“… 1997 πŸ› Elsevier Science 🌐 English βš– 270 KB

A series of 5,6-diarylimidazo[2.1-b]thiazole compounds were prepared and their inhibitory potencies against COX-2 and Cox-1 enzymes were measured. This led to the identification of L-766,112 as a potent, orally active and selective inhibitor of the COX-2 enzyme.