Synthesis and Biological Activity of 9-β-D-Ribofuranosyl-6-hydroxylaminopurine
✍ Scribed by Giner-Sorolla, Alfredo; Medrek, Lillian; Bendich, Aaron
- Book ID
- 127351728
- Publisher
- American Chemical Society
- Year
- 1966
- Tongue
- English
- Weight
- 280 KB
- Volume
- 9
- Category
- Article
- ISSN
- 0022-2623
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📜 SIMILAR VOLUMES
To date, all the known microbially-derived 4,5-linked aminoglycoside antibiotics contain a f3-D-pentofuranosyl moiety attached to carbon-5 of the deoxystreptamine portion, as in the paromomycin-neomycini-lividomycin', and ribo-stamycin3-butirosin4 groups.
A series of 6-substituted purine nucleosides have been synthesized in mcderate yield by the nickel catalyzed cross coupling reaction between alkyl-and aryl-Griqnard reagents and 2',3',5'-tris-@-(t-butyldimethylsilyl)-9-~-~-ribofuranosy1-6-chloropurine. Adenosine analogues with alkyl and aryl group l
Pyridin-2-one C-nucleoside 13 was prepared in 7 steps from 2-fluoropyridine 1 and D-ribono-l,4-1actone 2. The successful approach to ~i-ribofuranosides 12 and 13 consisted of the reductive opening of the furanose ring of hemiacetal 3 followed by intramolecular Mitsunobu cyclization.