Aminoglycoside antibiotics: synthesis of 6-0-(β-D-ribofuranosyl) paromamine
✍ Scribed by Tomoya Ogawa; Tetsuyoshi Takamoto; Stephen Hanessian
- Book ID
- 104243191
- Publisher
- Elsevier Science
- Year
- 1974
- Tongue
- French
- Weight
- 198 KB
- Volume
- 15
- Category
- Article
- ISSN
- 0040-4039
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✦ Synopsis
To date, all the known microbially-derived 4,5-linked aminoglycoside antibiotics contain a f3-D-pentofuranosyl moiety attached to carbon-5 of the deoxystreptamine portion, as in the paromomycin-neomycini-lividomycin', and ribo-stamycin3-butirosin4 groups.
📜 SIMILAR VOLUMES
A series of 6-substituted purine nucleosides have been synthesized in mcderate yield by the nickel catalyzed cross coupling reaction between alkyl-and aryl-Griqnard reagents and 2',3',5'-tris-@-(t-butyldimethylsilyl)-9-~-~-ribofuranosy1-6-chloropurine. Adenosine analogues with alkyl and aryl group l
Recent reports have dealt with the preparation of functionalized C-glycosyl compounds 2 as synthetic intermediates for the preparation of naturally occurring C-nucleosides and their analogues 2a\*d-g. As part of our general program on the synthesis of C-nucleosides, we have prepared the new C-glycos