## Abstract Two trisโalkoxycarbonyl homoarginine derivatives, BocโHar{ฯ,ฯโฒโ[Z(2Br)]~2~}โOH and BocโHar{ฯ,ฯโฒโ[Z(2Cl)]~2~}โOH, were prepared by guanidinylation of BocโLysโOH, and used for the synthesis of neoโendorphins and dynorphins. The results were compared with that obtained in the synthesis in
Synthesis and biological activities of neurokinin pseudopeptide analogues containing a reduced peptide bond
โ Scribed by D Jukic; M Mayer; P Schmitt; G Drapeau; D Regoli; R Michelot
- Publisher
- Elsevier Science
- Year
- 1991
- Tongue
- French
- Weight
- 870 KB
- Volume
- 26
- Category
- Article
- ISSN
- 0223-5234
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
The synthesis of the first all-aza-amino acid analogue (2) of a peptidic renin inhibitor is described. The X-ray structural analysis and molecular modelling investigations of this novel compound reveal interesting conformational features which have a significant impact on its biological activity. In
Benzo-fused model compounds 21a and 21b, resembling in structure the marine metabolite ptilomycalin A, were prepared and were shown to display significant activity against a series of cancer cell lines and to also possess a significant activity against the DNA polymerase activity of the reverse tran