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Synthesis and biological activity of analogues of ptilomycalin A

✍ Scribed by Gregory P Black; Simon J Coles; Amnon Hizi; Andrew G Howard-Jones; Michael B Hursthouse; Alan T McGown; Shoshana Loya; Christopher G Moore; Patrick J Murphy; Nigel K Smith; Nigel D.A Walshe

Publisher
Elsevier Science
Year
2001
Tongue
French
Weight
175 KB
Volume
42
Category
Article
ISSN
0040-4039

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✦ Synopsis

Benzo-fused model compounds 21a and 21b, resembling in structure the marine metabolite ptilomycalin A, were prepared and were shown to display significant activity against a series of cancer cell lines and to also possess a significant activity against the DNA polymerase activity of the reverse transcriptase of human immunodeficiency virus type 1 (HIV-1 RT).

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