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Synthesis and properties of the first all-aza analogue of a biologically active peptide

✍ Scribed by Prof. Dr. Joachim Gante; Michael Krug; Günter Lauterbach; Reinhard Weitzel; W. Hiller

Publisher
John Wiley and Sons
Year
1995
Tongue
English
Weight
370 KB
Volume
1
Category
Article
ISSN
1075-2617

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✦ Synopsis

The synthesis of the first all-aza-amino acid analogue (2) of a peptidic renin inhibitor is described. The X-ray structural analysis and molecular modelling investigations of this novel compound reveal interesting conformational features which have a significant impact on its biological activity. In addition, insight into conformational features of azapeptides in general in comparison with the corresponding purely peptidic compounds is given.

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