Synthesis and biologic evaluation of major metabolites of N-(2-chloroethyl)-N'-cyclohexyl-N-nitrosourea
β Scribed by Johnston, Thomas P.; McCaleb, George S.; Montgomery, John A.
- Book ID
- 120990515
- Publisher
- American Chemical Society
- Year
- 1975
- Tongue
- English
- Weight
- 530 KB
- Volume
- 18
- Category
- Article
- ISSN
- 0022-2623
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## Abstract [2β^13^C, 2β^14^C]2βAminoethanol hydrochloride was prepared in good yield from Na\*CN in a two step sequence by first converting the Na\*CN to OHCH~2~\*CN and then reducing the nitrile directly with a solution of boraneβtetrahydrofuran complex. The reaction procedure was simple and the
14C N-2-hydroxyethyl-N-nitrosourea was prepared at a specific activity of 30 mCi/mmol and 1 . 2 9 mCi/mmol by a two-step synthetic sequence using 14C ethanolamine as the labelled precursor. Its puri-fication was performed by IiPLC using a Lichrosorb-DIOL column eluted by ethyl ether.The overall radi