Synthesis and Bioactivities of α -Aminophosphonate Derivatives Containing Benzothiazole and Thiourea Moieties
✍ Scribed by Liu, Jing-Zi; Song, Bao-An; Bhadury, Pinaki S.; Hu, De-Yu; Yang, Song
- Book ID
- 121222949
- Publisher
- Taylor and Francis Group
- Year
- 2011
- Tongue
- English
- Weight
- 250 KB
- Volume
- 187
- Category
- Article
- ISSN
- 1042-6507
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In order to search for novel antitumor drugs with high activity and low toxicity, a series of novel organogermanium sesquioxides containing ␣aminophosphonate groups were synthesized by the hydrolysis of O,O-diphenyl N-trichlorogermylpropiono-␣-aminophosphonates. Their structures were confirmed by 1
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## Abstract A series of α‐aminophosphonate derivatives of 2′‐deoxyuridine (**8a–k**) have been prepared from 5′‐O‐tert‐butyldimethylsilyl‐3′‐amino‐2′, 3′‐dideoxyuridine in good yields. The structures of all the products were confirmed by ^1^H NMR, ^31^P NMR, ^31^C NMR, and IR spectroscopy, and mass