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Synthesis and bioactivities of novel organogermanium sesquioxides containingα-aminophosphonate groups

✍ Scribed by Qingmin Wang; Zhi Chen; Qiang Zeng; Runqiu Huang

Publisher
John Wiley and Sons
Year
1999
Tongue
English
Weight
128 KB
Volume
10
Category
Article
ISSN
1042-7163

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✦ Synopsis

In order to search for novel antitumor drugs with high activity and low toxicity, a series of novel organogermanium sesquioxides containing ␣aminophosphonate groups were synthesized by the hydrolysis of O,O-diphenyl N-trichlorogermylpropiono-␣-aminophosphonates.

Their structures were confirmed by 1 H NMR, 31 P NMR, and IR spectroscopy and by elemental analysis. Data of 1 H NMR and IR spectroscopy indicated that the title compounds are polymeric organogermanium sesquioxides. The results of bioassay showed that the products possess potential anticancer activities.

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