Synthesis and Bioactivities of Andrographolide Derivatives: New (−)-Limonidilactone Analogues

✍ Scribed by Haiwei Xu; Pingjuan Jiang; Weiyi Li; Junfeng Wang; Hongmin Liu

• Publisher: John Wiley and Sons
• Year: 2011
• Tongue: English
• Weight: 129 KB
• Volume: 29
• Category: Article
• ISSN: 0256-7660
• DOI: 10.1002/cjoc.201180366

✦ Synopsis

Abstract

In this study, a novel route to (−)‐limonidilactone analogues 10, 11 by way of stereoselective reaction of andrographolide (5) from 8, 9 was reported. The anti‐tumor and α‐glucosidsae inhibition activities of some synthetic compounds were screened.