Synthesis and Bioactivity of Aripiprazole Derivatives.
β Scribed by Hai-Xia Ge; Li-Chen Wang; Zhen-Zhou Jiang; Sheng-Liang Ni
- Publisher
- John Wiley and Sons
- Year
- 2007
- Weight
- 23 KB
- Volume
- 38
- Category
- Article
- ISSN
- 0931-7597
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## Abstract Some of the products show promising antiinflammatory and/or analgesic properties.
Scheme 2. Synthesis of indigo glycoside 7: a) KMnO 4 , AcOH, high-power stirring (12 000 rpm), 20 8C, 3-4 h; b) pyridine/toluene (1:2), 70 8C, 1 h; c) 1) 10, CH 2 Cl 2 , 2) Me 3 SiI, 20 8C, 30 min, 3) 3, 08C, 30 min, 4) nPrSH, 0!20 8C, 1 h, 5) Ac 2 O/pyridine (3:1), KHF 2 , 708C, 3 h; d) NaOtBu (15