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Synthesis and binding properties of 2H-1-benzopyran-2 one fluorophore-linked calcium channel antagonist nifedipine (1,4-dihydropyridine) analogs

✍ Scribed by Seetharamaiyer Padmanabhan; Ravikumar Peri; Aleta Rutledge; David J. Triggle

Publisher: Journal of Heterocyclic Chemistry
Year: 1997
Tongue: English
Weight: 284 KB
Volume: 34
Category: Article
ISSN: 0022-152X
DOI: 10.1002/jhet.5570340146

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✦ Synopsis

Abstract

Nifedipine analogs I, II and III with the 2__H__‐1‐benzopyran‐2‐one (coumarin) fluorophore linked at the 2, 2 and 6 and 4 positions of the dihydropyridine ring were synthesized by the modified Hantzch condensation procedures. Attempts to synthesize dihydropyridine with the fluorophore at position 3 (IV) were unsuccessful.

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