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ChemInform Abstract: Synthesis and Binding Properties of 2H-1-Benzopyran-2-one Fluorophore- Linked Calcium Channel Antagonist Nifedipine (1,4-Dihydropyridine) Analogues.

✍ Scribed by S. PADMANABHAN; R. PERI; A. RUTLEDGE; D. J. TRIGGLE

Publisher: John Wiley and Sons
Year: 2010
Weight: 35 KB
Volume: 28
Category: Article
ISSN: 0931-7597
DOI: 10.1002/chin.199728105

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✦ Synopsis

Synthesis and Binding Properties of 2H-1-Benzopyran-2-one Fluorophore-Linked Calcium Channel Antagonist Nifedipine (1,4-Dihydropyridine) Analogues. -Nifedipine analogues (VII), (VIII), and (XI) with a coumarin fluorophore linked at the 2-, 2,6-, and 4-position of the dihydropyridine ring, resp., are synthesized by modified Hantzsch condensation procedures and evaluated for their radioligand binding properties. Attempts to synthesize the nifedipine analogue (XII) having the fluorophore at the 3-position fail. -(PADMANABHAN, S.;

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